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本文报道利凡诺对小鼠Ｓ—１８０实体瘤生长的影响。经研究发现利凡诺高（４５ｍｇ／ｋｇ－１·ｄ－１）、中（３０ｍｇ／ｋｇ－１·ｄ－１）、低（１５ｍｇ／ｋｇ－１·ｄ－１）剂量组瘤重抑制率分别为４７．５％、２９．７５％和—２３．１４％，高剂量组和阳性药组平均瘤重明显低于对照组（Ｐ＜０．０５）。阳性药（氟尿嘧啶，１５ｍｇ／ｋｇ－１·ｄ－１）组瘤重抑制率为５２．０７％。采用高剂量利凡诺重复试验三次；疗效稳定，瘤重抑制率分别为５１．２２％、４７．１１％和５１．３８％，平均瘤重均低于各自对照组（ｐ＜０．０５）。结果表明该药对小鼠Ｓ—１８０实体瘤的生长有较明显的抑制作用。
This article reports the effect of rivanol on the growth of S-180 solid tumors in mice. The study found that the tumor weight inhibition rate of rivanol high (45mg/kg-1 ·d-1), medium (30mg/kg-1 · d-1), low (15mg/kg-1 · d-1) dose group They were 47.5%, 29.75%, and -23.14%, respectively. The average tumor weights in the high-dose group and the positive group were significantly lower than those in the control group (P<0.05). The inhibitory rate of tumor weight in the positive drug (fluorouracil, 15 mg/kg-1·d-1) group was 52.07%. The high dose of rivanol was repeated three times; the curative effect was stable, the tumor weight inhibition rates were 51.22%, 47.11%, and 51.38%, respectively, and the average tumor weight was lower than that in the control group (p<0.05). . The results showed that the drug had a significant inhibitory effect on the growth of mouse S-180 solid tumors.