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目的:探讨分析阿立哌唑治疗精神发育迟滞(MR)患儿的临床疗效。方法:随机选取2015年1月至2016年1月鹤壁市人民医院收治的MR患儿120例,随机分成两组,对照组:60例,应用氯氮平进行治疗;观察组:60例,应用阿立哌唑治疗,于治疗前、治疗2周、治疗4周,对比Conners父母量表评分。结果:治疗2周后,两组患儿的情感障碍、多动行为、学习问题、品行问题、冲动行为评分均显著降低,多动行为、学习问题、品行问题、冲动行为几个指标与治疗前比较,差异具有统计学意义(P<0.05);治疗4周后,两组患儿各项指标进一步改善,观察组患儿多动行为、学习问题、品行问题、冲动行为几个指标明显优于对照组,差异具有统计学意义(P<0.05)。结论:阿立哌唑治疗MR患儿的临床疗效确切。
Objective: To investigate the clinical efficacy of aripiprazole in the treatment of mental retardation (MR) in children. Methods: A total of 120 MR patients were randomly selected from Hebi Municipal People’s Hospital from January 2015 to January 2016. The patients were randomly divided into two groups: control group (60 cases), clozapine treatment group (60 cases), observation group Aripiprazole treatment, before treatment, treatment for 2 weeks, treatment for 4 weeks, compared with the Conners Parents Scale score. Results: After 2 weeks of treatment, the affective disorders, hyperactivity behaviors, learning problems, conduct problems and impulsive behavior scores of two groups were significantly decreased, and hyperactivity behaviors, learning problems, conduct problems and impulsive behaviors were significantly different from those before treatment (P <0.05). After 4 weeks of treatment, the indicators of children in both groups were further improved. The indexes of hyperactivity, learning, conduct and impulsivity in observation group were significantly better than those in observation group Control group, the difference was statistically significant (P <0.05). Conclusion: The clinical efficacy of aripiprazole in treating children with MR is exact.