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目的 :评价谷氨酰胺联合雷尼替丁对消化性溃疡的疗效。 方法 :采用随机双盲对照设计 ,5 9例患者随机分成验证组 17例 ,口服谷氨酰胺 5 0 0 mg,4次 /d,雷尼替丁 15 0 m g,2次 /d;对照组 2 2例 ,口服安慰剂 (淀粉胶囊 ) 2粒 ,4次 /d,雷尼替丁 15 0 mg2次 /d;开放组 (2 0例 )给药同验证组。疗程均为 4周。 结果 : 验证组 (胃溃疡 12例 ,十二指肠球部溃疡 5例 ) ,治愈率 35 .3% (6 /17) ,显效率 5 8.8% (10 /17) ,总有效率 94.1% (16 /17)。对照组 (胃溃疡11例 ,十二指肠球部溃疡 11例 ) ,治愈率 9.1% (2 /2 2 ) ,显效率 36 .4% (8/2 2 ) ,总有效率 86 .4% (19/2 2 )。 结论 :谷氨酰胺联合雷尼替丁治疗消化性溃疡疗效好 ,不良反应小。
OBJECTIVE: To evaluate the efficacy of glutamine combined with ranitidine on peptic ulcer. Methods: A randomized, double-blind, controlled trial was designed. Fifty-nine patients were randomly divided into 17 patients in the validation group, which received orally 50 mg of glutamine, 4 times daily and ranitidine 150 mg twice daily. Two patients received orally placebo (starch capsule) 2 capsules 4 times daily and ranitidine 150 mg twice daily, whereas the control group received 20 mg open dose. The course of treatment is 4 weeks. Results: In the validation group (gastric ulcer in 12 cases and duodenal ulcer in 5 cases), the cure rate was 35.3% (6/17), the effective rate was 8.88% (10/17), the total effective rate was 94.1% 16/17). In the control group, 11 cases were gastric ulcer and 11 cases were duodenal ulcer. The cure rate was 9.1% (2/2 2), the effective rate was 36.4% (8/2), the total effective rate was 86.4% (19/2 2). Conclusion: The combination of glutamine and ranitidine has good curative effect and little adverse reaction in the treatment of peptic ulcer.