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目的:通过对肝硬化等慢性肝病者血清中透明质酸(hyaluronic acid,HA)、Ⅲ型前胶原(p(?)gen tyeⅢ,pcⅢ)含量的检测,探讨肝纤维化血清学标志对慢性肝病的诊断价值.方法:以健康对照组和其他胃肠疾病组为对照,放射免疫分析法测定血清中HA、pcⅢ含量,并将各组结果进行统计学分析,比较(方差分析,线性回归分析).结果:肝硬化代偿、失代偿期两组血清HA、poⅢ含量均显著高于健康对照组与胃肠疾病组(p<0.001).肝硬化组中,Child-Pugh’s A.B.C三组及其积分与血清HA.peⅢ含量之间均有非常显著的正相关关系(p<0.001,p<0.01).以血清HA≥165ug/L或pcⅢ≥148.2ug/L为临界值(cut-off value)的联合诊断指标比单项指标好,其灵敏度、特异性、阳性预示值分别是0.77,0.94和0.97.结论:作者认为,血清HA.pcⅢ可作为肝硬化诊断,病情程度判断及疗效观察的无创伤性、可动态监测的指标.
OBJECTIVE: To detect the levels of hyaluronic acid (HA) and procollagen Ⅲ (Ⅲ) in cirrhotic patients with cirrhosis and other chronic liver diseases and to explore the effect of serum markers of liver fibrosis on chronic liver disease .Methods: The healthy control group and other gastrointestinal disease group as a control, radioimmunoassay method determination of serum HA, pcⅢ content, and the results of each group were statistically analyzed, compared (ANOVA, linear regression analysis) Results: The levels of serum HA and poⅢin decompensated liver cirrhosis and decompensated group were significantly higher than those in healthy control group and gastrointestinal disease group (p <0.001) .In cirrhotic group, the levels of Child-Pugh’s ABC and its (P <0.001, p <0.01) .However, the cut-off value of serum HA≥165ug / L or pcⅢ≥148.2ug / L was the most significant positive correlation , The sensitivity, specificity and positive predictive value were 0.77,0.94 and 0.97 respectively.Conclusion: The author believes that the serum HA.pcⅢ can be used as noninvasive diagnosis of cirrhosis, judging the severity of disease and the therapeutic effect Sexual, dynamically monitored indicators.