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为了界定什么是血液流变学药物，首先需要确定血液流变学的研究领域。生物流变学创始人Ａ．Ｌ．Ｃｏｐｌｅｙ认为血液流变学是研究血液与血管流动和变形的一门学科。它从宏观、细胞及分子不同水平研究有关的流变现象~（［１］）。Ｃｏｐｌｅｙ把血管和血液作为一个整体，称为“血管－血液器官”。血液流变学研究的内容应包括血液、血流与血管及其相互作用的诸多方面。因此，血液流变学药物（ｈｅｍｏｒｒｈｅｏｌｏｇｉｃａｌｓ）的范围相当广泛，应包括具有改善血液宏观流变性（血液与血浆粘度）的药物、改善红细胞变形性与聚集性的药物、调解白细胞流变性与粘附性的药物、抗血小板粘附与聚集的药物、降低纤维蛋白原药物、抗凝血药、溶解血栓药、血管扩张剂、血管收缩剂以及影响血管内皮功能的多种药物。 具有血液流变学活性的药物出现在血液流变学确立之前，而发展此类药物的重要性则在于它与危及生命的主要疾病有关，例如高血压、冠心病与脑血管病。在任何生理与病理过程中，血液、血流与血管都处于相互作用状态。 血管内皮细胞（ＥＣ）覆盖血管内表面，它是各件组织与血流之间的界面。ＥＣ的数量很可观，人体血管内皮的总面积达到８００～１０００ｍ~２，总重量达１．５ｋｇ。研究表明，ＥＣ可分泌?
In order to define what is a hemorheological drug, first of all need to determine the field of hemorheology. A. Rheumatism L. Copley believes that hemorheology is a discipline that studies the flow and deformation of blood and blood vessels. It studies macroscopic, cellular and molecular rheological phenomena related to different levels ~ ([1]). Copley treats blood vessels and blood as a whole, called “blood vessels - blood vessels.” Hemorheology should include blood, blood flow and blood vessels and their interactions in many aspects. Thus, a broad spectrum of hemorrheologicals should include drugs with improved blood macromolecular rheology (blood and plasma viscosity), drugs that improve erythrocyte deformability and aggregation, mediate leukocyte rheology and adherence , Anti-platelet adhesion and aggregation drugs, fibrinogen lowering agents, anticoagulants, thrombolytics, vasodilators, vasoconstrictors, and a variety of drugs that affect vascular endothelial function. Hemologically active drugs appear before hemorheology is established, and the importance of developing such drugs is that they are linked to the major life-threatening diseases such as hypertension, coronary heart disease and cerebrovascular disease. In any physiological and pathological process, blood, blood flow and blood vessels are in an interactive state. Vascular endothelial cells (ECs) cover the interior surface of blood vessels, which is the interface between the tissues and the bloodstream. The number of EC is very impressive, the total area of human vascular endothelial reached 800 ~ 1000m ~ 2, the total weight of 1.5kg. Research shows that EC can be secreted?