目的探讨降钙素原(PCT)和C反应蛋白(CRP)对ICU重型颅脑损伤患者发热原因的价值。方法采用前瞻性方法,选择我院ICU在2015年1月~2016年12月收治的76例重型颅脑损伤并发热患者,分析血清PCT和CRP水平与发热原因之间的关系。结果感染组患者较非感染组血清PCT和CRP水平升高,差异有统计学意义(P<0.05)。结论对重型颅脑损伤并发热患者行PCT和CRP检测,可以初步鉴别发热原因,指导临床治疗。 Objective To investigate the value of procalcitonin (PCT) and C-reactive protein (CRP) on the causes of fever in ICU patients with severe craniocerebral injury. Methods A prospective study was conducted to determine the relationship between the serum PCT and CRP levels and the causes of fever in 76 patients with severe head injury and fever who were admitted to our hospital from January 2015 to December 2016. Results The levels of serum PCT and CRP in infected patients were significantly higher than those in non-infected patients (P <0.05). Conclusion The detection of PCT and CRP in patients with severe craniocerebral injury and fever can initially identify the causes of fever and guide the clinical treatment.