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[目的]观察康复新液治疗儿童消化性溃疡(PU)的疗效及安全性。[方法]将204例PU患儿随机分为2组。对照组102例,幽门螺杆菌(Hp)阴性者给予奥美拉唑治疗,20~40mg/d,分1~2次口服;Hp阳性者在Hp阴性者治疗方法基础上,加用克拉霉素(15mg·kg-1·d-1,分2次口服)、甲硝唑(20~50mg·kg-1·d-1,分2次口服)、阿莫西林(20~40mg·kg-1·d-1,分2次口服,最多不超过2g)中的2种抗Hp治疗1周。治疗组102例,在对照组Hp阴性、Hp阳性者治疗基础上给予康复新液5ml/次,3次/d,口服。[结果]对照组疗程结束后溃疡愈合率85.29%,Hp根除率77.61%;2周内症状缓解率74.51%,疗程结束后症状缓解率86.27%。治疗组溃疡愈合率97.06%,Hp根除率77.14%;2周内症状缓解率89.22%,疗程结束后症状缓解率97.06%;2例出现恶心,对症治疗后症状好转,继续服药未再出现。2组比较,治疗组在溃疡愈合率及症状缓解率方面优于对照组(P<0.05),在Hp根除率方面差异无统计学意义。[结论]康复新液可促进儿童PU创面的愈合及减轻患儿症状,无明显不良反应。
[Objective] To observe the curative effect and safety of Kangfuxin solution on children’s peptic ulcer (PU). [Methods] 204 cases of PU children were randomly divided into two groups. In the control group, 102 patients with H.pylori (Hp) were given omeprazole 20 ~ 40mg / d orally for 1 or 2 times. Hp-positive patients were treated with clarithromycin (15mg · kg-1 · d-1 orally twice daily), metronidazole (20 ~ 50mg · kg-1 · d-1 orally twice daily), amoxicillin (20-40mg · kg-1 · D-1, orally 2 times, up to 2g) in the 2 anti-Hp treatment for 1 week. The treatment group of 102 cases, Hp-negative in the control group, Hp-positive treatment based on the rehabilitation of the new liquid 5ml / times, 3 times / d, orally. [Result] The healing rate of ulcer in the control group was 85.29% and the rate of Hp eradication was 77.61%. The symptom relief rate was 74.51% in 2 weeks, and the symptom relief rate was 86.27% after the course of treatment. In the treatment group, the healing rate of ulcer was 97.06% and the rate of Hp eradication was 77.14%. The symptom relief rate was 89.22% within 2 weeks and 97.06% after the course of treatment. The nausea and symptomatic treatment improved the symptoms in 2 cases and did not appear again. Compared with the control group, the treatment group was superior to the control group in healing rate and symptom relief rate (P <0.05), but there was no significant difference in the eradication rate of Hp between the two groups. [Conclusion] Kangfuxin solution can promote the healing of children PU wounds and relieve the symptoms of children without obvious adverse reactions.