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选择性环氧合酶-2抑制剂具有较理想的抗炎镇痛作用,而且其不良反应较非选择性NSAIDs明显减少,被广泛应用于治疗关节炎的疼痛和其他疼痛的治疗。本文对选择性环氧合酶-2抑制剂如美洛昔康、尼美舒利、塞来昔布和帕瑞昔布等临床应用及不良反应进行评价。
Selective cyclooxygenase-2 inhibitors have better anti-inflammatory and analgesic effects, and their adverse reactions are significantly reduced compared with non-selective NSAIDs. They are widely used in the treatment of arthritis pain and other pain. This article evaluates the clinical use and adverse effects of selective cyclooxygenase-2 inhibitors such as meloxicam, nimesulide, celecoxib, and parecoxib.