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目的：探讨女性系统性红斑狼疮（ＳＬＥ）患者脂质紊乱与蛋白代谢异常的关系。方法：对３２例女性ＳＬＥ患者与对照组血脂情况进行比较；并将ＳＬＥ患者分成血浆白蛋白≤３ｇ／ｄｌ１４例与＞３ｇ／ｄｌ１８例两组，以及分成２４小时尿蛋白定量＞０５ｇ１８例与≤０５ｇ１４例，分别比较其血脂情况。结果：（１）ＳＬＥ组中总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、脂蛋白（ａ）（Ｌｐ（ａ））较对照组升高（Ｐ＜００１）；载脂蛋白Ａ１（ａｐｏＡ１）、ａｐｏＡ１／ａｐｏＢ较对照组降低（Ｐ＜００１）；（２）血浆白蛋白≤３ｇ／ｄｌ组ＴＣ、Ｌｐ（ａ）较＞３ｇ／ｄｌ组升高（Ｐ＜００５）；（３）２４小时尿蛋白定量＞０５ｇ组ＴＣ、Ｌｐ（ａ）较≤０５ｇ组升高（Ｐ＜００５）。结论：女性ＳＬＥ患者存在较高的血脂异常发生率（８１２％），血浆白蛋白水平和２４小时尿蛋白排出量对血脂影响较大，其中对ＴＣ、Ｌｐ（ａ）影响更大。提示：积极控制尿蛋白和纠正低蛋白血症对防治血脂代谢紊乱十分重要。
Objective: To investigate the relationship between lipid disorders and protein metabolism in female patients with systemic lupus erythematosus (SLE). Methods: Thirty-two female patients with SLE were compared with the control group. The patients with SLE were divided into two groups of 14 patients with serum albumin ≤3g / dl and> 3g / dl18, and the patients with SLE were divided into 24 patients with urine protein> 05g18 And ≤ 0 5g 14 cases, respectively, compare the situation of blood lipids. Results: (1) The total cholesterol (TC), triglyceride (TG) and lipoprotein (a) (Lp (a)) in SLE group were higher than those in control group apoA1 and apoA1 / apoB were lower than those in the control group (P <001); (2) TC and Lp (a) in plasma albumin ≤3g / dl group were higher than those in the group of> ; (3) 24 hour urine protein> 05g group TC, Lp (a) than ≤ 0.5g group increased (P <0 05). CONCLUSIONS: The prevalence of dyslipidemia in women with SLE is high (812%). Serum albumin level and 24-hour urinary protein excretion have a significant effect on blood lipids, especially TC and Lp (a). Tip: Positive control of urinary protein and correct hypoalbuminemia is very important for the prevention and treatment of dyslipidemia.