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目的 :探讨曲尼司特配成缓释制剂后 ,其平喘作用的延长效果。方法 :用豚鼠引喘实验法。设计 4个实验组 ,分别给药后测定潜伏期 ,比较潜伏期的变化及显著性。结果 :曲尼司特有显著平喘效果 ,其缓释制剂组与空白组、阳性对照组比较 ,豚鼠的潜伏期显著延长。结论 :曲尼司特缓释制剂的缓释效果显著 ,药效作用明显延长。
OBJECTIVE: To investigate the prolonged antiasthmatic effects of tranilast formulated into sustained release formulations. Methods: Guinea pigs asthma experimental method. Four experimental groups were designed and tested for latency after administration, and the changes and significance of latency were compared. Results: Tranilast had a significant antiasthmatic effect. Compared with the blank control group and the positive control group, the incubation period of guinea pigs was significantly prolonged in the sustained release formulation group. Conclusion: The sustained-release effect of tranilast sustained release formulations was significant, and the pharmacodynamic effects were significantly prolonged.