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细胞间粘附分子 - 1(ICAM- 1)和血管细胞间粘附分子 - 1(VCAM- 1)属于免疫球蛋白超家族 (IGSF)成员。人 ICAM- 1基因定位于染色体 19p13.3～ 13.2区 ,长 15 .5 kb,其受体为淋巴细胞功能相关抗原 - 1(L FA- 1,CD11a/ CD18)和 Mac- 1;VCAM- 1基因定位于染色体 1p31～ 32区 ,长约 2 5 kb,其受体为极迟抗原 - 4 (VL A- 4 )和整合素α4β7。 ICAM- 1和 VCAM- 1的表达受 NF-κB、SP1、GATA、PKC、STAT- 1等相关的机制所调控
Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) belong to the immunoglobulin superfamily (IGSF). The human ICAM-1 gene is located on the chromosome 19p13.3-13.2 region and is 15.5 kb in length. The receptor for human ICAM-1 gene is LFA-1, CD11a / CD18 and Mac-1. VCAM-1 The gene is located on chromosome 1p31 ~ 32 and is about 25 kb in length. Its receptor is VL-4 (VL-4) and integrin α4β7. The expression of ICAM-1 and VCAM-1 is regulated by the related mechanisms of NF-κB, SP1, GATA, PKC and STAT-1