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目的研究壳聚糖创面修复膜凝胶预防会阴侧切切口感染的效果,以降低感染发生率。方法选取2013年5月-2015年5月在医院分娩的200例产妇作为研究对象,所有产妇均行会阴侧切术,将产妇随机分为4组,其中壳聚糖创面修复膜凝胶组(CG组)、红霉素软膏组(EO组)、聚维酮碘组(I组)和头孢拉定胶囊组(CC组),每组各50例,比较各组产妇切口感染率、切口愈合及水肿程度、视觉模拟(VAS)评分及伤口愈合时间。结果切口感染率CG组及EO组均为0、I组及CC组均为2.0%,差异无统计学意义;各组产妇切口愈合和水肿程度,差异无统计学意义;VAS评分与切口愈合时间,CG组为(2.7±0.6)分与(6.6±1.8)d;EO组为(4.1±0.5)分与(8.9±1.7)d;I组为(5.5±0.8)分与(11.5±2.6)d;CC组为(5.8±0.7)分与(12.4±2.4)d,差异有统计学意义(P<0.05)。结论壳聚糖创面修复凝胶可以预防会阴侧切口感染,缩短切口的愈合时间。
Objective To study the effect of chitosan wound repair membrane gel on the prevention of perineal incision infection in order to reduce the incidence of infection. Methods A total of 200 maternal women delivered in the hospital from May 2013 to May 2015 were enrolled in this study. All the women underwent perineal excision. The women were randomly divided into 4 groups. The chitosan wound healing group (CG (EO group), povidone-iodine group (I group) and cefradine capsule group (CC group), 50 cases in each group. The infection rate of incision, incision healing and edema degree in each group were compared , Visual analogue (VAS) score and wound healing time. Results Incision infection rate was 0 in CG group and EO group, 2.0% in I group and CC group, with no significant difference. There was no significant difference in incision healing and edema between the two groups. VAS score and incision healing time (5.5 ± 0.8) and (11.5 ± 2.6) points in the I group were (2.7 ± 0.6) points and (6.6 ± 1.8) days respectively in the CG group and (4.1 ± 0.5) points and 8.9 ± 1.7 days in the EO group d. The CC group was (5.8 ± 0.7) points and (12.4 ± 2.4) days, respectively, with significant difference (P <0.05). Conclusion Chitosan wound repair gel can prevent perineal incision infection and shorten the incision healing time.