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试用环戊基哌嗪力复毒素(R-77-3)治疗5例多菌型麻风病人,並于治疗前后用鼠足垫技术测定药物的杀菌效果。2例一次监服R-77-3900mg,3例一次监服1200mg。实验表明服R-77-3以前取自5例病人的菌株均能使C57BL/6N小鼠感染成功,菌量增多11.3～80倍;在服药之后7天取得的菌株均不能使小鼠足垫感染成功,2例查不到抗酸菌,3例仅见繁殖的迹象。这证明R-77-3治疗麻风具有强力而快速的作用,不过一次剂量还不能完全杀灭麻风菌,仍有少量存活者。
The trial of cyclopentylpiperazine reuptake (R-77-3) treatment of 5 cases of multi-type leprosy patients, and before and after treatment with a mouse foot pad technique to determine the bactericidal effect of the drug. 2 cases once supervised service R-77-3900mg, 3 cases once supervised service 1200mg. Experiments show that the strain taken from 5 patients before taking R-77-3 can successfully infect C57BL / 6N mice with an increase of 11.3- to 80-fold. After 7 days of taking the drug, none of the strains obtained mouse foot pad Infection was successful, 2 cases of acid-fast bacteria were not found, and 3 cases only showed signs of reproduction. This proved that R-77-3 treatment of leprosy has a strong and rapid effect, but one dose can not completely kill leprosy, there are still a small number of survivors.