Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction.Protocatechuic aldehyde(PCA)is a major phenolic acid in Chinese herb Danshen(SSalvia miltiorrhiza root).This study investigated whether PCA regulate
Dioxin-like molecules have been associated with endocrine disruption and liver disease.To better understand aryl hydrocarbon receptor(AHR)biology,metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body g
The cell cycle inhibitor P21 has been implicated in cell senescence and plays an important role in the injury-repair process following lung injury.Pulmonary fibrosis(PF)is a fibrotic lung disorder characterized by cell senescence in lung alveolar epitheli
The drug formulation design of self-emulsifying drug delivery systems(SEDDS)often re-quires numerous experiments,which are time-and money-consuming.This research aimed to rationally design the SEDDS formulation by the integrated computational and experime
Pyrrolizidine alkaloids(PAs)are the most common phytotoxins with documented human hepatotoxicity.PAs require metabolic activation by cytochromes P450 to generate toxic intermediates which bind to proteins and form protein adducts,thereby causing cytotoxic
Traditional chemotherapy exhibits a certain therapeutic effect toward malignant cancer,but easily induce tumor multidrug resistance(MDR),thereby resulting in the progress of tumor recurrence or metastasis.In this work,we deigned ternary hybrid nanodrugs(P
改革开放42年来,中国经济实现了年均9％以上的增长速度,创造了世界经济发展史上的奇迹.在这42年中,经济第一省(自治区、直辖市、特别行政区)的位置也曾数易其主.1979年,江苏超越上海,成为内地第一经济大省,在之后的11年间,除了1982、1983、1984、1985年山东以微弱优势超越江苏外,江苏有7年都保持着内地第一经济大省的地位.
We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regener-ation after acetaminophen(APAP)hepatotoxicity.Here,we hypothesized that exogenous PA is also bene-ficial.To test that,we treated mice with a toxic APAP dose at 0 h,foll
苏州,明清时期我国“制造业”的中心城市rn清乾隆十一年(公元1 746年),纳兰常安正处于自己仕途的巅峰.在历任太原府通判、冀宁道、山西粮驿道、广西按察使、云南布政使、江西巡抚、盛京兵部侍郎、刑部侍郎、漕运总督后,他在浙江巡抚的位置上己任职5年.多年来宦海沉浮、游历四方的经历,让他领略了各地不同的舆地风土,见识了诸多奇闻异事,他将这些内容都写入了自己的著作《受宜堂宦游笔记》之中.在所到过的诸地中,有一处城市之繁华、商贸之兴盛、物产之精美,令他叹为观止:他写到苏州“制造百物”:“苏州专诸巷,琢玉、雕金、镂木
Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains unclear.In this study,we established a novel primary vesical calculi model with D,L-choline tartrate in mice.Compared with commonly used melamine and ethylen