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目的观察含奥沙利铂方案经皮肝动脉化疗栓塞术(TACE)治疗肝癌的临床疗效和不良反应。方法对68例肝癌患者进行含奥沙利铂方案的TACE治疗,每例完成2~3次后评价疗效及不良反应。结果 68例中完全缓解(CR)8例(11.8%),部分缓解(PR)55例(80.9%),稳定(SD)2例(2.9%),进展(PD)3例(4.4%),总有效率为92.6%(63/68)。甲胎蛋白下降幅度为86.7%(52/60)。主要不良反应为胃肠道反应及白细胞减少。结论含奥沙利铂方案TACE治疗肝癌的疗效较好,临床症状显著改善,不良反应轻。
Objective To observe the clinical efficacy and adverse reactions of oxaliplatin-containing transcatheter arterial chemoembolization (TACE) in the treatment of liver cancer. Methods Sixty-eight patients with hepatocellular carcinoma were treated with oxaliplatin-containing TACE. Efficacy and adverse reactions were evaluated after 2 or 3 times of complete remission. Results Eighty patients (11.8%) with complete remission (CR), 55 (80.9%) with partial remission (PR), 2 with stable (SD) and 2.9 with progressive (PD) The total effective rate was 92.6% (63/68). Alpha-fetoprotein decreased by 86.7% (52/60). The main adverse reactions are gastrointestinal reactions and leukopenia. Conclusions TACE with oxaliplatin regimen has a good curative effect on hepatocellular carcinoma, with significant improvement of clinical symptoms and mild adverse reactions.