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目的探讨美托洛尔与贝那普利联合治疗慢性心力衰竭的临床疗效。方法选择慢性心力衰竭患者69例,随机分成治疗组38例和对照组31例,对照组给予利尿剂、强心剂、硝酸酯类等扩血管药物常规治疗,治疗组在常规治疗的基础上加用美托洛尔和贝那普利,半年后比较两组在治疗前后6min内步行距离、左室射血分数、左室舒张末期内径、左室收缩末期内径的变化及心功能改善情况。结果治疗前后6min内步行距离、左室射血分数、左室舒张末期内径、左室收缩末期内径的变化比较差异均有统计学意义(P<0.05),治疗组心功能改善显效率(52.6%)及总有效率(92.1%)明显优于对照组(19.3%)、(64.5%)(P<0.01),差异有统计学意义。结论美托洛尔联合贝那普利治疗慢性心力衰竭的临床疗效可靠,可改善患者的预后,提高生活质量。
Objective To investigate the clinical efficacy of metoprolol combined with benazepril in the treatment of chronic heart failure. Methods Sixty-nine patients with chronic heart failure were randomly divided into treatment group (n = 38) and control group (n = 31). The control group was given routine treatment of vasodilators, cardiac drugs and nitrates. The treatment group Propranolol and propranolol, six months later, the walking distance, left ventricular ejection fraction, left ventricular end-diastolic dimension, left ventricular end-diastolic diameter, and cardiac function were compared between the two groups before and after 6 months. Results The changes of walking distance, left ventricular ejection fraction, left ventricular end-diastolic diameter and left ventricular end-diastolic diameter within 6 minutes before and after treatment were significantly different (P <0.05), and the improvement of cardiac function in treatment group was significant (52.6% ) And total effective rate (92.1%) were significantly better than the control group (19.3%), (64.5%) (P <0.01), the difference was statistically significant. Conclusion The combination of metoprolol and benazepril in the treatment of chronic heart failure has reliable curative effect, which can improve the prognosis of patients and improve the quality of life.