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目的探讨癌胚抗原CA199表达在卵巢成熟性畸胎瘤诊断中的临床意义。方法选取2015年1月—2016年1月新沂市人民医院收治的55例卵巢成熟性畸胎瘤患者的临床资料,所有患者依次行CA199、CA125、CEA、AFP检测,设行CA199检测为A组,行CA125检测为B组,行癌胚抗原(CEA)检测为C组,行甲胎蛋白(AFP)检测为D组。取患者外周静脉血5ml检测其CA199、CA125、CEA、AFP水平,其中CA199、CA125、CEA、AFP临界值分别为:39U/ml、35U/ml、5ng/ml、13.6ng/ml。比较4组检测结果。结果 A组阳性检出率高于B、C、D组,且CA199升高组肿瘤直径大于CA199正常组,差异有统计学意义(P<0.05);双侧卵巢畸胎瘤CA199血清水平与单侧卵巢畸胎瘤CA199血清水平比较,差异无统计学意义(P>0.05)。结论检测血清中癌胚抗原CA199水平可有效诊断并判断卵巢成熟性畸胎瘤大小。
Objective To investigate the clinical significance of carcinoembryonic antigen CA199 expression in the diagnosis of ovarian mature teratoma. Methods The clinical data of 55 patients with mature ovarian teratoma from January 2015 to January 2016 in Xinyi People’s Hospital were enrolled. All patients were followed by CA199, CA125, CEA and AFP tests. Group, line CA125 test for the B group, line carcinoembryonic antigen (CEA) test for the C group, line AFP test for the D group. The patients with peripheral venous blood 5ml detection CA199, CA125, CEA, AFP levels, including CA199, CA125, CEA, AFP critical values were: 39U / ml 35U / ml 5ng / ml 13.6ng / ml. Compare 4 groups of test results. Results The positive detection rate of group A was higher than that of group B, C and D, and the diameter of CA199 elevated group was larger than that of CA199 normal group (P <0.05). The serum level of CA199 in bilateral ovarian teratoma was significantly higher than that of single The ovarian teratoma CA199 serum levels, the difference was not statistically significant (P> 0.05). Conclusion Detection of CA199 in serum can effectively diagnose and determine the size of mature ovarian teratoma.