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对HBV标志阴性的95名少年以乙肝疫苗10μg×3的免疫剂量和0、1、2个月的免疫程序进行接种(接种组),并对无乙肝疫苗接种史而在筛查时曾受HBV感染恢复并产生抗-HBs的63名同类少年(自然组)作了为期5年的追踪观察。结果表明,接种组抗-HBs阳转率在T_3时为98.95％,其S/N均值为66.31,在T_(60)时抗-HBs阳性率仍有72.63％,其S/N均值降至9.18,但有26名抗-HBs转阴。此外,接种组和自然组间的血清抗-HBs转换率及其S/N均值变化的比较均有显著性差异(P<0.01)。
Ninety-five juveniles with negative HBV markers were vaccinated (inoculated group) with an immunization dose of 10 μg × 3 for hepatitis B vaccine and an immunization schedule of 0, 1, and 2 months, and were vaccinated against the history of hepatitis B vaccination at the time of screening Sixty-three follow-up studies were performed on 63 similar adolescents (natural group) who recovered and developed anti-HBs. The results showed that the positive rate of anti-HBs in vaccinated group was 98.95% at T_3, the average S / N was 66.31, and the positive rate of anti-HBs was still 72.63% at T_ (60) , But 26 anti-HBs turned negative. In addition, the serum anti-HBs conversion rate and the S / N mean change between the vaccinated group and the natural group were significantly different (P <0.01).