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消化系统恶性肿瘤在我国具有较高的发病率和病死率,目前的治疗手段主要有手术、放疗、化疗、介入治疗、生物免疫治疗和中医中药治疗等方法,但是对中晚期肿瘤患者效果往往较差,而且消化系统恶性肿瘤早期诊断率低.因此深入研究其发病机制至关重要.近年来国内外学者研究发现PTEN通过多种细胞内信号传导参与细胞生长与增殖,并与多种消化系统恶性肿瘤发生、发展及预后有关,因此阐明PTEN在消化系统恶性肿瘤中的作用机制非常重要,且PTEN有望成为消化系统恶性肿瘤治疗的新靶点.该文就该基因在消化系统恶性肿瘤中的研究进展做一综述.“,”The digestive system malignant tumors has a high morbidity and mortality in our country,and the current treatment methods include surgery,radiotherapy,chemotherapy,interventional therapy,biological immunotherapy and traditional Chinese medicine treatment.But at present the effect of treatment is poor for patients of advanced cancer.And the early diagnosis rate of malignant tumor in digestive system is low.So it is very important to study the pathogenesis of the disease.In recent years,scholars at home and abroad found PTEN gene participated in cell growth and proliferation by multiple intracellular signal transduction,and was related to the occurrence and development and prognosis of malignant tumors of digestive system.Therefore,it is very important to clarify the mechanism of PTEN in the malignant tumors of digestive system.And PTEN is expected to become the new target for cancer treatment.This paper will review the research progress of PTEN in the digestive system malignant tumors.