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目的探讨奥美拉唑联合左氧氟沙星、阿莫西林克拉维酸钾三联疗法根除幽门螺杆菌(Hp)的疗效。方法将78例Hp阳性的慢性胃炎患者随机分为2组,每组各39例。2组基线资料匹配。治疗组采用三联疗法(左氧氟沙星+阿莫西林克拉维酸钾,奥美拉唑),对照组单用奥美拉唑,2组均治疗7d。治疗结束后4周复查,进行胃镜检查取胃黏膜做快速尿素酶试验(RUT)、组织学检查和13C-尿素呼气检查(13C-UBT)。3项均阴性者视为Hp根除。结果治疗组症状均有不同程度改善,治疗组和对照组Hp根除率分别为84.6%和46.2%,差异有统计学意义(P<0.05)。结论含左氧氟沙星的三联疗法根除Hp疗效较好。
Objective To investigate the efficacy of omeprazole combined with levofloxacin and amoxicillin-trimetazidine in the eradication of Helicobacter pylori (Hp). Methods 78 chronic Hp-positive chronic gastritis patients were randomly divided into two groups, 39 cases in each group. 2 sets of baseline data match. The treatment group with triple therapy (levofloxacin + amoxicillin and clavulanate potassium, omeprazole), the control group with omeprazole alone, two groups were treated for 7 days. Four weeks after the end of treatment, the gastric mucosa was examined by gastroscopy for rapid urease test (RUT), histological examination and 13C-urea breath test (13C-UBT). 3 were negative as Hp eradication. Results The symptoms of the treatment group improved to some extent. The Hp eradication rates in the treatment group and the control group were 84.6% and 46.2%, respectively, with statistical significance (P <0.05). Conclusions Triple therapy with levofloxacin has good efficacy in eradicating Hp.