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目的:研究止咳平喘颗粒的镇咳、祛痰、平喘的相关药理作用,为临床应用提供依据。方法:分别做镇咳、祛痰、平喘试验,每个实验取小鼠50只,分阴性、阳性及止咳平喘颗粒高、中、低三个剂量组,观察咳嗽潜伏期及次数、酚红排泌量;急性毒性试验,以止咳平喘颗粒最大剂量灌胃,观察毒性反应。结果:止咳平喘颗粒能延长咳嗽及引喘潜伏期,减少咳嗽次数,增加酚红排泌量。未见毒副反应。结论:止咳平喘颗粒有很好的止咳、祛痰、平喘作用;安全性很高。
Objective: To study the antitussive, expectorant and antiasthmatic effects of Zhike Pingchuan Granules in order to provide the basis for clinical application. Methods: Antitussive, expectorant and antiasthmatic tests were performed respectively. 50 mice in each experiment were divided into three groups: high, middle, and low doses of cough and asthma. The latency and number of cough were observed. Phenol red Excretion; acute toxicity test, the cough and asthma particles maximum dose of gavage, observe the toxicity. Results: Cough and asthma can prolong cough and lead asthma latency, reduce the number of cough, increase the secretion of phenol red. No toxic side effects. Conclusion: Cough and asthma granules have good cough, expectorant, antiasthmatic effect; high safety.