以商业化供应的天然产物白桦脂醇为原料,首先经高价碘试剂IBX选择性氧化生成桦木酮醛,然后经四丁基高锰酸铵氧化以86%的总收率制得标题化合物。氧化剂IBX可以方便、有效地回收并再循环。该方法操作简便,具有潜在的工业化前景。 Commercially available natural product, betulin, was used as the starting material for the selective oxidation of betulinic aldehyde to IBX by the hypervalent iodine reagent, followed by oxidation with tetrabutylammonium permanganate to give the title compound in 86% overall yield. The oxidizer IBX can be conveniently and efficiently recovered and recycled. The method is easy to operate and has potential industrialization prospects.