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目的 检测妊娠高血压综合征 (妊高征 )患者外周血中总同型半胱氨酸 (tHcy)的水平 ,并探讨其与妊高征发病的关系。方法 应用高效液相色谱电化学检测 (HPLC ED)法检测未妊娠妇女、正常妊娠妇女以及妊高征患者血清中tHcy的水平。结果 ①非妊娠组的tHcy水平 [(7.89± 2 .6 2 )mol/L]与正常妊娠组 [(5 .91± 1.96 ) μmol/L]相比较 ,差异有极显著性 (P <0 .0 0 1) ;正常妊娠组在孕中期tHcy水平 [(5 .2 3± 1.88) μmol/L]降至最低。②妊高征组tHcy水平 [(9.40± 3.0 6 ) μmol/L]明显高于正常妊娠组 (P <0 .0 0 1) ,与非妊娠组妇女相比较 ,tHcy水平呈逐渐升高趋势 (P值分别小于 0 .0 5 ,0 .0 1,0 .0 0 1) ;并随妊高征病情的加重 ,tHcy水平呈逐渐上升趋势 ,重度妊高征明显高于轻度妊高征 (P <0 .0 5 )。结论 妊娠后tHcy水平显著升高可能是妊高征发病机制中的一个重要因素。
Objective To detect the level of total homocysteine (tHcy) in peripheral blood of patients with pregnancy induced hypertension (PIH) and to explore its relationship with the pathogenesis of PIH. Methods The level of tHcy in sera of pregnant women, normal pregnant women and patients with pregnancy induced hypertension was detected by HPLC-ED method. Results ① The level of tHcy in non-pregnant group [(7.89 ± 2.62) mol / L] was significantly higher than that in normal pregnancy group [(5.91 ± 1.96) μmol / L] 0 0 1). The level of tHcy in the third trimester of pregnant women [(5.23 ± 1.88) μmol / L] was reduced to the lowest level. ② The level of tHcy in PIH group was significantly higher than that in non-pregnant group ([9.40 ± 3.06] μmol / L] (P <0.01), and the level of tHcy was gradually increased P values were less than 0.05, 0.010 and 0.010 respectively). With the worsening of pregnancy-induced hypertension, the level of tHcy was gradually increased and the rate of severe pregnancy-induced hypertension was significantly higher than that of mild pregnancy-induced hypertension P <0. 05). Conclusion The significant increase of tHcy after pregnancy may be an important factor in the pathogenesis of PIH.