论文部分内容阅读
[目的]对大鼠慢性轻度不可预见性的应激(CUMS)模型进行胃肠感觉和动力等方面的评估。[方法]将模型大鼠分为CUMS组和对照组,分别于实验前后检测2组大鼠动力(排便颗粒、排便时间)、感觉(自发性腹外斜肌收缩)和行为/心理(糖水摄取量、体质量)等指标改变。[结果]1CUMS组大鼠实验后出现糖水摄取量明显下降、体质量增长缓慢现象,与对照组比较均差异有统计学意义(P<0.01);2气囊容量在0.8 ml和1.2 ml时,CUMS组腹部收缩次数增加,与对照组比较均差异有统计学意义(P<0.01);3CUMS组大鼠的直肠传输时间与对照组无明显差别(P>0.05)。[结论]CUMS抑郁模型可作为研究心理行为障碍与内脏感觉异常相关性机制的平台,尤其针对那些胃肠动力无明显改变者。
[Objective] To evaluate the gastrointestinal sensation and motility of chronic mild unpredictable stress rats (CUMS) model. [Methods] The model rats were divided into CUMS group and control group. The rats’ motility (defecation granules, defecation time), sensation (spontaneous abdominal oblique contraction) and behavior / psychology Volume, body mass) and other indicators change. [Results] The rats in 1CUMS group had significantly decreased intake of carbohydrate and slow body weight increase after the experiment, showing significant difference compared with the control group (P <0.01). When the volume of the balloon was 0.8 ml and 1.2 ml, CUMS (P <0.01). The rectal transit time in 3CUMS group was not significantly different from that in control group (P> 0.05). [Conclusions] The CUMS depression model can be used as a platform to study the correlation between mental and behavioral disorders and visceral abnormalities, especially for those with no significant changes in gastrointestinal motility.