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目的研究肾小管功能测定预测成人原发肾病综合征（ＡＩＮＳ）的可行性及可靠性。方法将ＡＩＮＳ患者分为尿β２微球蛋白（β２ＭＧ）正常组（Ａ）、升高组（Ｂ），比较其对激素的敏感性，并与病理分型作对比研究。结果①肾小管功能损害有随病程延长而加重的趋势。②Ａ组激素完全缓解率明显高于Ｂ组（Ｐ＜０．０１）。尿β２ＭＧ升高是激素不敏感的危险因素。③病理分型中微小病变与系膜增生型激素完全缓解率与其它类型无差别。结论尿β２ＭＧ正常可作为预测ＡＩＮＳ患者对激素敏感的依据，敏感性０．８５１，特异性０．９０８，并且ＡＩＮＳ患者应尽早治疗
Objective To investigate the feasibility and reliability of renal tubular function test in predicting adult primary nephrotic syndrome (AINS). Methods AINS patients were divided into normal group (β2MG) of urinary β2 microglobulin (A), elevated group (B), and compared their sensitivity to hormones, and compared with the pathological typing. Results ① The renal tubular dysfunction increased with the duration of the disease. ② The complete remission rate of hormones in group A was significantly higher than that in group B (P <0.01). Increased urinary β2MG is a hormone-insensitive risk factor. ③ Pathological classification of minimal changes and mesangial proliferative hormone complete remission rate and other types of no difference. Conclusion Urine β2MG normal can be used as a basis for the prediction of hormone sensitivity in patients with AINS, with a sensitivity of 0.851 and a specificity of 0.908. Patients with AINS should be treated as soon as possible