目的:探讨二甲双胍治疗老年糖尿病患者的疗效及安全性。方法:72例老年糖尿病患者随机分为观察组与对照组各36例。观察组采用二甲双胍片治疗,对照组给予瑞格列奈片,疗程均为8周。比较两组的疗效及安全性。结果:两组治疗后空腹、三餐后2 h及晚10点时的血糖值均较前显著下降(P<0.05);观察组治疗后空腹血糖水平明显低于对照组(P<0.05),其他时间点血糖值与对照组比较差异无统计学意义(P>0.05)。观察组治疗后HbA1c水平明显低于治疗前(P<0.05),对照组治疗前后HbA1c水平差异无统计学意义(P>0.05)。观察组药品不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:二甲双胍在治疗老年患者糖尿病治疗中效果显著,安全性高,值得进一步推广应用。 Objective: To investigate the efficacy and safety of metformin in the treatment of elderly diabetic patients. Methods: 72 cases of elderly diabetic patients were randomly divided into observation group and control group, 36 cases each. The observation group was treated with metformin tablets, the control group was given repaglinide tablets, the course of treatment was 8 weeks. The curative effect and safety of the two groups were compared. Results: The fasting blood glucose, fasting blood glucose at two hours and three o’clock after meal in both groups were significantly lower than those before (P <0.05); the fasting blood glucose level in the observation group was significantly lower than that in the control group (P <0.05) There was no significant difference in blood glucose level between the control group and other time points (P> 0.05). The level of HbA1c in the observation group was significantly lower than that before treatment (P <0.05), while there was no significant difference in the level of HbA1c in the control group before and after treatment (P> 0.05). The incidence of adverse drug reactions in the observation group was lower than that in the control group, with significant difference (P <0.05). Conclusion: Metformin is effective and effective in the treatment of diabetes mellitus in elderly patients. It is worth further promotion and application.