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目的 评价综合护理干预的应用对新生儿坏死性小肠结肠炎预后情况的影响。方法 选择医院收治的80例住院治疗的坏死性小肠结肠炎新生儿为研究对象，选取时间问为2018年6月至2019年6月。在对症支持治疗的基础上进行随机分组护理，对照组与试验组分别采取常规护理以及综合护理干预，各40例。对比两组的治疗效果、并发症发生率以及家属护理满意度评分、患儿住院时间。结果 试验组患儿家属护理满意度评分高于对照组，患儿住院时间短于试验1组，患儿呼吸衰竭、肠穿孔等并发症发生率低于对照组，P＜0.05。两组治疗效果比较，P＞0.0“,”Objective To evaluate the effect of comprehensive nursing intervention on the prognosis of neonatal necrotizing enterocolitis.Methods A total of 80 cases of necrotizing enterocolitis were admitted to our hospital from June 2018 to June 2019.On the basis of symptomatic support treatment，the patients were randomly divided into two groups，the first group and the second group were adopted routine nursing and comprehensive nursing intervention，40 cases in each group.The therapeutic effect，complication rate，nursing satisfaction score of family members and hospitalization time of neonates with necrotizing enterocolitis were compared between two and groups.Results The nursing satisfaction score of the family members of the two groups was higher than that of the first group，the hospitalization time of the children was shorter than that of the first group，and the incidence of complications such as respiratory failure and intestinal perforation was lower than that of the first group(P＜0.05).The therapeutic effect was compared between groups(P＞0.05).Conclusion The treatment of necrotizing enterocolitis in newborn combined with comprehensive nursing intervention can further promote the prognosis and improve the safety of children，and the overall nursing effect is significant.