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系统性自身免疫病的特征之一是循环中出现一些抗核蛋白的自身抗体。多数自身抗体，除抗ＤＮＡ抗体外，在自身免疫病的病理机制中并无直接作用。然而，特异性自身抗体与相应的自身免疫病病情高度相关。探讨自身免疫病中的抗原抗体作用有助于我们了解自身免疫病的发病机制，为疾
One of the hallmarks of systemic autoimmune disease is the appearance of autoantibodies against the nucleoprotein in the circulation. Most autoantibodies, in addition to anti-DNA antibodies, have no direct effect on the pathogenesis of autoimmune diseases. However, specific autoantibodies are highly correlated with the condition of the corresponding autoimmune disease. To explore the role of antigens and autoantibodies in autoimmune diseases helps us to understand the pathogenesis of autoimmune diseases.