苯妥英钠超敏反应早在1936年就有报道,1979年Fred Haruda报告38例有出疹、发热、淋巴结增生肿大、肝功损害、白细胞减少、血小板减少、嗜酸细胞增多、贫血、蛋白尿及肾功能衰竭(Neurology 29(11):1480 1979)。因此用苯妥英钠治疗癫痫的过程中值得注意,我院收治一例,报告如下。男,20岁,1979年来无任何诱因反复出现四肢抽搐、口吐白沫、不省人事,每次持续10分钟左右。入院后又有两次典型癫痫大发作。以往无过敏史及特殊病史。体查:心肺、腹部及神经系统未发现异常。血、尿、粪常规检查正常,肝功能检查、头颅X光平 Phenytoin hypersensitivity was reported as early as 1936. In 1979, Fred Haruda reported 38 cases of rash, fever, lymph node hyperplasia, liver damage, leukopenia, thrombocytopenia, eosinophilia, anemia, proteinuria And renal failure (Neurology 29 (11): 1480 1979). Therefore, phenytoin treatment of epilepsy is worth noting that our hospital admitted to a case, the report is as follows. Male, 20 years old, 1979 without any incentives repeated limbs twitch, foaming at the mouth, unconsciousness, each lasting about 10 minutes. After admission, there are two typical epileptic seizures. In the past no history of allergies and special medical history. Physical examination: heart and lungs, abdomen and nervous system found no abnormalities. Normal blood, urine, feces routine examination, liver function tests, skull X-ray