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目的 观察服用格列吡嗪控释片 (瑞易宁 )治疗 2型糖尿病的临床疗效 ,并与每日 2、 3次服用格列齐特 (达美康 )作为对照 ,以评价两者是否具有相同的降血糖效果。方法 选择 80例老年 2型糖尿病患者 ,随机分为瑞易宁组 (4 0例 )和达美康组 (4 0例 ) ,进行治疗和比较。结果 治疗 8周后两组空腹血糖水平 (FBG)、餐后 2小时血糖、糖基化血红蛋白 (Hb Alc)均有显著下降。瑞易宁组 FBG下降 2 .1 5 mm ol/ L,Hb Alc下降 0 .72 % (P均<0 .0 5 ) ;达美康组 FBG下降 2 .1 0 m mol/ L ,Hb Alc下降 0 .73% ,(P均 <0 .0 5 ) ;组间比较差异无显著性 (P>0 .0 5 )。两组均未见明显的不良反应 ,瑞易宁组治疗后血清胆固醇及甘油三酯较治疗前有明显下降 ,而达美康组无变化。结论 对 2型糖尿病患者每日 1次服用瑞易宁可有效控制血糖水平 ,与每日多次服用达美康疗效相似 ,且耐受性良好。
Objective To observe the clinical efficacy of glipizide controlled-release tablets (Rui Yi Ning) in the treatment of type 2 diabetes mellitus (T2DM) and to compare with two or three daily doses of gliclazide (Deltamex) as control The same hypoglycemic effect. Methods Eighty elderly patients with type 2 diabetes mellitus were randomly divided into Rui-ning group (40 cases) and da-meikang group (40 cases) for treatment and comparison. Results After 8 weeks of treatment, fasting blood glucose (FBG), postprandial blood glucose 2 hours, and glycosylated hemoglobin (Hb Alc) were significantly decreased. (P <0.05). The FBG decreased and the Hb Alc decreased by 0.72% (P <0.05) in Eminence group, FBG decreased 2.10 mmol / L and Hb Alc decreased 0.73% (P <0.05). There was no significant difference between the two groups (P> 0.05). There were no obvious adverse reactions in both groups. Serum cholesterol and triglyceride of Ruianning group were significantly lower than those before treatment, but there was no change in the control group. Conclusion Ruianning daily in patients with type 2 diabetes mellitus can effectively control blood sugar levels, which is similar to that of taking metmyolume multiple times daily, and is well tolerated.