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目的:研究核孔蛋白复合体蛋白88(Nup88)mRNA在乳腺癌组织中的表达及其与临床病理特征的关系。方法:RT-PCR法检测40例乳腺癌及40例乳腺良性病变组织中Nup88mRNA的表达水平。结果:Nup88mRNA在乳腺癌组织中的表达水平显著高于乳腺良性病变(P<0.001);乳腺癌组织学分化越低、临床TNM分期越晚、淋巴结有转移,Nup88mRNA表达水平越高(均P<0.05);Nup88mRNA表达与cerbB-2蛋白表达呈显著正相关(P<0.05)。结论:Nup88与乳腺癌的发生发展有关,其表达可作为评估乳腺癌生物学行为的指标之一。
Objective: To study the expression of nuclear nuclease complex 88 (Nup88) mRNA in breast cancer and its relationship with clinicopathological features. Methods: The expression of Nup88 mRNA in 40 cases of breast cancer and 40 cases of benign breast lesions was detected by RT-PCR. Results: The expression of Nup88 mRNA in breast cancer tissues was significantly higher than that in benign breast lesions (P <0.001). The lower the histological differentiation was, the later clinical TNM stage was, the lymph node was metastasized and the expression of Nup88 mRNA was higher (all P < 0.05). There was a significant positive correlation between Nup88mRNA and cerbB-2 protein expression (P <0.05). Conclusion: Nup88 is associated with the occurrence and development of breast cancer, and its expression may be used as an index to evaluate the biological behavior of breast cancer.