梅毒螺旋体(Tp)目前尚不能体外培养,抗原获取困难,从而影响到Tp致病机制、实验室诊断方法及疫苗的研究。随着分子生物学技术的发展和Tp全基因序列的解析、多种重组Tp膜蛋白的成功表达及其结构功能的日益明确,为Tp发病机理的研究、诊断方法的更新和疫苗的研制奠定了良好的基础。 Treponema pallidum (Tp) is not yet cultured in vitro, antigen acquisition difficulties, thus affecting the pathogenesis of Tp, laboratory diagnostic methods and vaccine research. With the development of molecular biology techniques and the analysis of Tp complete genome sequence, the successful expression of a variety of recombinant Tp membrane proteins and their increasingly clear structural function have laid the foundation for the study on the pathogenesis of Tp, the update of diagnostic methods and the development of vaccines Good foundation.