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环孢素Cyclosporine A,简称(CsA)的临床应用明显地改善了器官移植的效果,但仍有一些问题尚待解决,如该药价格昂贵、常引起高血压、肾中毒等。移植术后应用钙通道阻滞剂(CCB)可提高CsA血浓度,预防急性CsA肾中毒、减少急性肾小管坏死的发生。本文借助回顾性资料研究CCB在稳定的移植受体内对CsA的临床及生物学影响。共30例患者,其中肾移植28例、胰肾移植1例、肝移植1例;平均年龄41.6岁(22～60岁);男性19例、女性11例;患者分3组各在应用CsA期间分别用硫氮唑酮、异搏
The clinical application of Cyclosporine A (CsA) has obviously improved the effect of organ transplantation. However, some problems remain to be solved. For example, the drug is expensive and often causes high blood pressure and kidney toxicity. Application of calcium channel blockers (CCB) after transplantation can increase CsA blood concentration, prevent acute CsA nephrotoxicity and reduce the incidence of acute tubular necrosis. In this review, retrospective data were used to investigate the clinical and biological effects of CCB on CsA in stable transplant recipients. A total of 30 patients, including renal transplantation in 28 cases, 1 case of pancreas and kidney transplantation, liver transplantation in 1 case; mean age 41.6 years (22 to 60 years); 19 males and 11 females; Respectively with thiadiazole, verapamil