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自70年代末在东非报告第一例氯喹抗性疟疾后,迅速传播至中非及西非,现在撒哈拉以南的所有非洲国家都已有抗性的报道。为了评价中、西非洲的抗性势态,作者于1986—1991年间,对在70个法国协作中心的门诊或住院的感染恶性疟的旅游者进行了氯喹敏感性体外测定。将患者静脉血收集在合构椽酸盐的管内,并冷藏送回法国,仅以原虫密度0.1％—1.0％的血样作分析。采用半微量测定法判断其敏感性,求出50％的抑制浓度
After the first case of chloroquine-resistant malaria was reported in East Africa in the late 1970s, it spread rapidly to Central and West Africa and all the African countries now sub-Saharan have been reported to have resistance. In order to evaluate the resistance state in Central and West Africa, during 1986-1991, the authors conducted a chloroquine sensitive in vitro assay for tourists infected with falciparum malaria at outpatient or in-hospital outpatient centers in 70 French collaborating centers. The patient’s venous blood is collected in a tube of synthetic rafters and refrigerated back to France and analyzed only for blood samples with a protozoal density of 0.1% -1.0%. Semi-micro assay to determine its sensitivity, to find 50% inhibitory concentration