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使用抗生素,预计最佳剂量和最合适的用药间歇时间可根据该抗生素的药代动力学特点,针对的菌株以及防止副作用等来安排。病人情况尚佳,用标准剂量的抗生素即能有效,即使药效尚嫌不足,病人有抵抗力往往能弥补,临床也不一定需作调整。但是当病人抵抗力明显减退,则抗生素剂量,给药方法和间隔时间就很重要。出血性休克直接影响免疫应答,抗生素的效力降低,选用头孢菌素类抗生素就必需增量。作者为了观察出血性休克抗御感染用等量头孢唑啉(cefa-zolin)是否点滴优于间断给药,而做了动物实验。作者给Sprague-Dawley雌鼠的腹腔内注氯胺酮和甲苯噻嗪(xylazine)麻醉,用肝素后放血使平均动脉压达45mmHg持续45分钟,再回输放出的血液和盐水使血压恢复。另一部分大鼠只做虚假手术(sham
With antibiotics, the optimal dose and the most suitable dosing interval are expected to be based on the pharmacokinetic profile of the antibiotic, the strain to be targeted, and the prevention of side effects and the like. Patients are still good, with standard doses of antibiotics that can be effective, even if the effect is still inadequate, the patient often can make up for the resistance, the clinical does not necessarily need to be adjusted. However, when the patient’s resistance is significantly diminished, the dosage of antibiotics, the method of administration and the interval are important. Hemorrhagic shock directly affects the immune response, reduce the effectiveness of antibiotics, the choice of cephalosporins antibiotics will need to increase. The authors performed animal experiments to see if cefa-zolin was superior to intermittent dosing with hemorrhagic shock against infection. Sprague-Dawley female rats were anesthetized with intraperitoneal injection of ketamine and xylazine, and then hemodynamically deprived of blood by heparin for a mean arterial pressure of 45 mmHg for 45 minutes. The returned blood and saline were then returned to restore blood pressure. Another part of rats only do sham surgery (sham