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目的:探讨原发性高血压患者血清瘦素、抵抗素水平的变化及与颈动脉粥样硬化的相关关系。方法:入选80例原发性高血压患者(病例组),另选32例健康对照者。采用酶联免疫吸附法检测血清瘦素、抵抗素水平;采用彩色超声诊断仪测定颈动脉内膜-中层厚度(IMT)。结果:病例组的瘦素(t=-2.530,P=0.013)和抵抗素水平(t=-2.077,P=0.041)均高于对照组。病例组的颈动脉IMT(t=-3.115,P=0.003)和颈动脉最大IMT(t=-3.271,P=0.002)均大于对照组。Pearson相关分析示,高血压患者血清瘦素与IMT(r=0.311,P=0.012)和最大IMT(r=0.308,P=0.013)呈显著正相关;血清抵抗素与IMT(r=0.335,P=0.006)和最大IMT(r=0.284,P=0.022)呈显著正相关。结论:原发性高血压患者的血清瘦素、抵抗素水平显著升高,且它们和颈动脉IMT存在相关性。
Objective: To investigate the changes of serum leptin and resistin levels in patients with essential hypertension and its relationship with carotid atherosclerosis. Methods: Eighty patients with essential hypertension (case group) and 32 healthy controls were enrolled. Serum leptin and resistin levels were measured by enzyme-linked immunosorbent assay. Carotid intima-media thickness (IMT) was measured by color sonography. Results: Leptin (t = -2.530, P = 0.013) and resistin level (t = -2.077, P = 0.041) in the case group were higher than those in the control group. The carotid IMT (t = -3.115, P = 0.003) and carotid IMT (t = -3.271, P = 0.002) were higher in the case group than in the control group. Pearson correlation analysis showed that serum leptin was positively correlated with IMT (r = 0.311, P = 0.012) and maximum IMT (r = 0.308, P = 0.013) = 0.006) and the maximum IMT (r = 0.284, P = 0.022) was significantly positive correlation. Conclusion: The levels of serum leptin and resistin in patients with essential hypertension are significantly increased, and they are correlated with carotid IMT.