The Nain and Ashin ophiolites consist of Mesozoic mélange units that were emplaced in the Late Cretaceous onto the continental basement of the Central-East Iran microcontinent (CEIM). They largely consist of serpentinized peridotites slices;nonetheless, minor tectonic slices of sheeted dykes and pillow lavas - locally stratigraphically associated with radiolarian cherts - can be found in these ophiolitic mélanges. Based on their whole rock geochemistry and mineral chemistry, these rocks can be divided into two geochemical groups. The sheeted dykes and most of the pillow lavas show island arc tholeiitic (IAT) affinity, whereas a few pillow lavas from the Nain ophiolites show calc-alkaline (CA) affinity. Petrogenetic modeling based on trace elements composition indicates that both IAT and CA rocks derived from partial melting of depleted mantle sources that underwent enrichment in subduction-derived components prior to melting. Petrogenetic modeling shows that these components were represented by pure aqueous fluids, or sediment melts, or a combination of both, suggesting that the studied rocks were formed in an arc-forearc tectonic setting. Our new biostratigraphic data indicate this arc-forearc setting was active in the Early Cretaceous. Previous tectonic interpretations suggested that the Nain ophiolites formed, in a Late Cretaceous backarc basin located in the south of the CEIM (the so-called Nain-Baft basin). However, recent studies showed that the CEIM underwent a counter-clockwise rota-tion in the Cenozoic, which displaced the Nain and Ashin ophiolites in their present day position from an original northeastward location. This evidence combined with our new data and a comparison of the chemical features of volcanic rocks from different ophiolites around the CEIM allow us to suggest that the Nain-Ashin volcanic rocks and dykes were formed in a volcanic arc that developed on the north margin of the CEIM during the Early Cretaceous in association with the subduction, below the CEIM, of a Neo-Tethys oceanic branch that was existing between the CEIM and the south margin of Eurasia. As a major conclusion of this paper, a new geodynamic model for the Cretaceous evolution of the CEIM and surrounding Neo-Tethyan oceanic basins is proposed.