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甲状腺微粒体抗体(TMA)不仅存在于一些甲状腺疾患病人血清中,而且可能与病毒性疾病及其它非甲状腺自身免疫性疾病有关。于人群中检出率高达12%,高龄者可更高。但 TMA 的诊断和病理学意义不清楚。于1975年用免疫荧光法对2,838名成人进行血清TMA 鉴定。其中1,587名于1969年也曾被试验过。对在2次调查均检出 TMA 的对象和117名 TMA 阴性的健康成人对照者用加倍抗体放射免疫测定法测定血清促甲状腺激素(TSH)。对照组平均 TSH 为1.0(范围0.2～13.6)mU/L,其中2名在参考范围限度(3.6mU/L)之上,分别为6.1和13.6mU/L。结果 1975年调查的2,838名对象,190名(6.7%)为 TMA 阳性。女性对象 TMA 阳性率为9.8%,男
Thyroid microsomal antibody (TMA) not only exists in the serum of some patients with thyroid disease, but also may be related to viral diseases and other non-thyroid autoimmune diseases. The detection rate in the population of up to 12%, elderly may be higher. However, the diagnostic and pathological significance of TMA is not clear. In 1975, 2,838 adults were tested for serum TMA by immunofluorescence. 1,587 of them were also tested in 1969. Serum thyrotropin (TSH) was measured by double antibody radioimmunoassay in subjects with TMA detected in both surveys and 117 TMA-negative healthy adult controls. The control group had an average TSH of 1.0 (range 0.2 to 13.6) mU / L, with two of them over the reference range limit of 3.6 mU / L, which were 6.1 and 13.6 mU / L, respectively. Results Of 2,838 subjects surveyed in 1975, 190 (6.7%) were TMA positive. Female TMA positive rate of 9.8%, male