新生儿持续肺动脉高压(PPHN)是一种与一系列心肺疾病相关联的综合征,以明显的肺动脉压升高及血管反应性异常为特征,并导致动脉导管和卵圆孔水平的右向左分流和严重的低氧血症,并常常对吸氧及血管扩张剂等治疗缺乏良好的反应。PPHN常与严重的肺实质性疾病有关(如肺发育不良、胎 Pulmonary Hypertension (PPHN), a neonatal continuum, is a syndrome associated with a range of cardiopulmonary diseases characterized by marked elevation of pulmonary arterial pressure and vascular reactivity abnormalities and leads to right-to-left arterial ductus and foramen ovale Shunt and severe hypoxemia, and often lack good response to treatment with oxygen and vasodilators. PPHN often associated with severe pulmonary parenchymal disease (such as lung dysplasia, fetal