应用非脱钙骨组织形态测量、单光子吸收扫描、骨物理测量方法对链脲佐菌素所致的慢性糖尿病鼠及对照鼠的骨组织形态、骨矿物质含量、骨生长和钙磷代谢进行了7周观察和研究。结果提示:糖尿病鼠可发生高尿钙、高尿磷、高血磷、显著的骨量减少和骨生长受抑。骨量减少的组织学基础为成骨细胞活性降低、骨形成和矿化不良。破骨细胞活性相对增高,骨吸收多于骨形成,骨重建单位负平衡。 Application of non-decalcified bone morphometry, single-photon absorption scan, bone physical measurements of bone tissue morphology, bone mineral content, bone growth and calcium and phosphorus metabolism in streptozotocin-induced chronic diabetic mice and control mice 7 weeks of observation and research. The results suggest that diabetic rats can develop high urinary calcium, high urinary phosphorus, high phosphorus, significant bone loss and bone growth inhibition. The histological basis for osteopenia is decreased osteoblast activity, bone formation and poor mineralization. Relatively increased activity of osteoclasts, bone resorption than bone formation, bone remodeling unit negative balance.