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目的探讨多囊卵巢综合征(PCOS)对超重或肥胖孕妇围产结局的影响。方法对2008年5月至2010年7月在北京妇产医院产科门诊初次就诊孕妇进行PCOS史的筛查,将55例体重指数(BMI)≥24PCOS合并妊娠的单胎孕妇作为研究组,将对照组按年龄及孕前BMI和研究组进行2:1配对,即110例符合条件的非PCOS孕妇被纳入对照组,随访两组的妊娠结局到分娩。多胎妊娠、原有高血压、糖尿病、高血脂、甲状腺功能异常、心脏病、肾脏病等慢性疾病者未纳入本研究。结果 BMI≥24PCOS孕妇早产的发生率(20.0%)明显高于对照组(5.5%),两组差异有统计学意义,P<0.01。而妊娠期糖尿病(GDM)、妊娠期高血压、子痫前期、产后出血等妊娠并发症及新生儿并发症发生率两组比较差异无统计学意义(P>0.05)。结论 PCOS没有增加超重或肥胖孕妇GDM及妊娠期高血压疾病及其他不良围产结局发生的危险,但早产发生的危险显著增高。
Objective To investigate the effect of polycystic ovary syndrome (PCOS) on perinatal outcome of overweight or obese pregnant women. Methods From May 2008 to July 2010 in Beijing Obstetrics and Gynecology Hospital outpatient clinic for the first time screening for PCOS history of pregnant women, 55 cases of body mass index (BMI) ≥ 24PCOS pregnancy with singleton pregnant women as the study group, the control Group according to age and pre-pregnancy BMI and the study group 2: 1 matching, that is, 110 cases of non-PCOS pregnant women were included in the control group, followed up two groups of pregnancy outcomes to delivery. Multiple pregnancies, hypertension, diabetes, hyperlipidemia, thyroid dysfunction, heart disease, kidney disease and other chronic diseases were not included in this study. Results The incidence of preterm birth in pregnant women with BMI≥24PCOS (20.0%) was significantly higher than that in the control group (5.5%). There was significant difference between the two groups (P <0.01). The gestational diabetes mellitus (GDM), gestational hypertension, preeclampsia, postpartum hemorrhage and other complications of pregnancy and complications of neonatal complications was no significant difference between the two groups (P> 0.05). Conclusions PCOS did not increase the risk of GDM, gestational hypertension and other adverse perinatal outcomes in overweight or obese pregnant women, but the risk of preterm birth was significantly higher.