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目的比较口服常规剂量甲泼尼龙和泼尼松对原发性肾病综合症的临床疗效。方法选取原发性肾病综合症患者68例,随机分为两组,对照组给予泼尼松,治疗组给予甲泼尼龙,观察两组患者的24小时尿蛋白定量,血常规,尿常规,肝肾功能,血脂,血糖及电解质。结果两组患者在8周和12周时有效率差异无显著性;治疗组因激素撤减引起的复发和反跳明显少于对照组,且较少发生肝功能损害。结论甲泼尼龙可避免由于激素撤减引起的复发和反跳,且不良反应较泼尼松少。
Objective To compare the clinical efficacy of oral conventional doses of methylprednisolone and prednisone on primary nephrotic syndrome. Methods Sixty-eight patients with primary nephrotic syndrome were selected and randomly divided into two groups. The control group was given prednisone. The treatment group was given methylprednisolone. The 24-hour urinary protein, blood routine, urine routine, Kidney function, blood lipids, blood glucose and electrolytes. Results There was no significant difference in the effective rate between the two groups at 8 weeks and 12 weeks. The relapse and rebound caused by hormone withdrawal in the treatment group was significantly less than that in the control group, and the incidence of liver dysfunction was less. Conclusion Methylprednisolone can avoid relapse and rebound caused by hormone withdrawal, and the adverse reaction is less than that of prednisone.