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目的研究黄芪甲苷配伍冰片前后在大鼠小肠的吸收情况。方法采用大鼠原位肠循环灌注实验法研究黄芪甲苷配伍冰片前后体内吸收动力学的具体变化。结果黄芪甲苷在5~20 mg·kg-1内的吸收动力学参数无显著性差异;2.5 mg·kg-1冰片与黄芪甲苷配伍前后的动力学参数无显著性差异,而5,10 mg·kg-1冰片配伍前后有显著性差异(P<0.01),但5,10 mg·kg-1剂量组之间的动力学参数差异不显著。结论冰片在一定的剂量范围内可促进黄芪甲苷在大鼠小肠内的吸收,可与黄芪甲苷配伍应用以提高生物利用度。
Objective To study the absorption of astragaloside and borneol in the small intestine of rats. Methods The in situ intestinal perfusion experiment was used to study the changes of in vivo absorption kinetics of astragaloside and borneol. Results There was no significant difference in absorption kinetics parameters of Astragaloside between 5 mg · kg-1 and 20 mg · kg-1. There was no significant difference in the kinetic parameters between 2.5 mg · kg-1 borneol and Astragaloside. mg · kg-1 borneol had significant difference before and after compatibility (P <0.01), but there was no significant difference in kinetic parameters between 5 and 10 mg · kg-1 groups. Conclusion Borneol can promote the absorption of astragaloside IV in the small intestine of rats in a certain dose range, and can be used in combination with astragaloside IV in order to improve the bioavailability.