论文部分内容阅读
目的:观察早期肠内营养中添加ω-3脂肪酸对重型颅脑损伤病人术后的治疗效果。方法:将45例重型颅脑损伤手术病人随机分成试验组和对照组,根据病情需要,对病人行开颅手术治疗后,分别行早期肠内免疫营养和早期常规肠内营养,进行等热量和等氮量的营养支持。在手术前、术后第7和第15天测定T细胞亚群、淋巴细胞总数、血清清蛋白水平,并统计感染并发症的发生率,比较两组病人术后第15天格拉斯哥昏迷(GCS)评分和术后3个月的预后(GOS)评分情况。结果:与对照组比,试验组病人T细胞亚群和淋巴细胞总数明显回升,感染并发症的发生率下降,术后第15天GCS评分增高(P<0.05)。试验组病人预后较好者GOS评分明显高于对照组(P<0.05)。血清清蛋白水平两组无统计学差异。结论:应用ω-3脂肪酸免疫营养支持能改善病人的营养状况,提高免疫功能,降低感染率,改善预后。
Objective: To observe the effect of adding omega-3 fatty acids in early enteral nutrition on patients with severe craniocerebral injury. Methods: Forty-five patients with severe craniocerebral trauma were randomly divided into experimental group and control group. According to the condition of the patients, after craniotomy treatment, early enteral immunization and early routine enteral nutrition were performed respectively, Nitrogen nutrition support. The T lymphocyte subsets, lymphocyte count and serum albumin level were measured before surgery and 7th and 15th days postoperatively. The incidence of infection complications was also compared. On the 15th day after operation, the Glasgow coma (GCS) Score and postoperative 3 month prognosis (GOS) score. Results: Compared with the control group, the T lymphocyte subsets and lymphocytes in the experimental group increased significantly and the incidence of infectious complications decreased. On the 15th day after operation, the GCS score increased (P <0.05). The GOS score of patients in trial group with better prognosis was significantly higher than that in control group (P <0.05). Serum albumin levels were no significant difference between the two groups. Conclusion: The application of omega-3 fatty acid immune nutrition support can improve the patient’s nutritional status, improve immune function, reduce the infection rate and improve the prognosis.