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本文报告12例小儿膜性肾病,占同期肾活检病例的11.5%。12例均为继发性,其中乙肝肾炎9例(男8,女1),狼疮肾炎3例(均为女孩)。临床均有明显水肿、蛋白尿或/及血尿,11例表现为肾病综合征。对激素多不敏感,但经持续治疗或/与免疫抑制剂联合治疗半效获缓解。2例经免疫酶标法证实肾小球有HBsAg沉积,2例狼疮肾炎因多系统损害不明显曾误诊,后经肾活检确诊,提示在小儿当肾组织为膜性改变时,应查找原因。
This article reports 12 cases of children with membranous nephropathy, accounting for 11.5% of the same period of renal biopsy cases. 12 cases were secondary, including hepatitis B nephritis in 9 cases (male 8, female 1), lupus nephritis in 3 cases (both girls). Clinical significantly edema, proteinuria or / and hematuria, 11 cases showed nephrotic syndrome. Not sensitive to the hormone, but after continuous treatment or / and immunosuppressive agents combined with half the effect was relieved. 2 cases confirmed by immune enzyme-labeled glomerular HBsAg deposition, 2 cases of lupus nephritis due to multiple system damage was not significantly diagnosed by the renal biopsy confirmed, suggesting that when the kidneys as membranous changes in renal tissue, should find the cause.