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目的:探讨血小板活化因子分解酶(PA F-A H)基因多态性在儿童过敏性紫癜(H SP)中的意义。方法:选择2002年9月至2004年2月诊断H SP患儿40例,其中男22例,女18例,年龄2～16(7.6±2.8)岁,伴肾脏损害17例。采用聚合酶链反应(PC R)方法检测PA F-A H基因型,并与40例健康儿童做对照。结果:H SP组与健康对照组基因型分布比较差异无显著意义(P>0.05),17例伴肾脏损害患儿即紫癜性肾炎(H SPN)组与健康对照组基因型分布比较差异有显著意义(P<0.05)。结论:H SP患儿肾脏损害的发生与PA F-A H基因多态性相关,具有G T及TT基因型者发生肾脏损害的机会增多。
Objective: To investigate the significance of polymorphism of platelet-activating factor (PA F-A H) gene in children with Henoch-Schonlein purpura (H SP). Methods: From September 2002 to February 2004, 40 children with H-SP were diagnosed, including 22 males and 18 females, aged from 2 to 16 (7.6 ± 2.8) years with 17 cases of renal damage. PA F-A H genotypes were detected by polymerase chain reaction (PCR) and compared with 40 healthy children. Results: There was no significant difference in genotype distribution between H SP group and healthy control group (P> 0.05). There was significant difference in genotype distribution between H SPN group and healthy control group in 17 children with renal impairment Significance (P <0.05). CONCLUSIONS: The incidence of kidney damage in children with H-SP is associated with a polymorphism in PA F-A H gene. There is an increased chance of kidney damage in the G T and TT genotypes.