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盐酸纳络酮(naloxone hydrochloride,NAL)为羟(二)氢吗啡酮的衍生物,为特异性的阿片受体拮抗剂。随着研究的深入,NAL越来越广泛地用于临床各科,尤其在内儿科方面有其显著的作用,下面就谈谈NAL在内儿科的应用现状。 1 治疗镇静催眠药中毒 在镇静催眠药过量的情况,脑内β-内腓肽释放增加,作用于阿片受体后引起中枢抑制和呼吸抑制,同时β-内腓肽亦可抑制前列腺素和儿茶酚胺的心血管效应,使心率减慢,血压下降。NAL为特异性阿片受体拮抗剂,它可兴奋交感—肾上腺髓质,增强儿茶酚胺的作用,并改善细胞ATP代谢,使细胞内cAMP增多,血乳酸
Naloxone hydrochloride (NAL) is a derivative of hydromorphone and is a specific opioid receptor antagonist. With the deepening of research, NAL is more and more widely used in clinical departments, especially in the internal pediatric has its significant role, the following will talk about the application of NAL pediatric status. 1 treatment sedative hypnotic poisoning In the case of sedation hypnosis over the brain, β-endorphin release increased, acting on opioid receptors cause central inhibition and respiratory depression, while β-endoprin can inhibit prostaglandins and catecholamines The cardiovascular effect, so that heart rate slowed, blood pressure. NAL is a specific opioid receptor antagonist, which can stimulate the sympathetic - adrenal medulla, enhance the role of catecholamines, and improve cellular ATP metabolism, intracellular cAMP increased blood lactate