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金制剂用于类风湿性关节炎的治疗。曾经有人研究了金进入人乳的途径,但对所提供的数据和使用的方法据认为是不适当的。现已进行了对两名哺乳期妇女使用硫代苹果酸金(50mg和70mg,分剂量给药数天)的研究。其中一名病人在妊娠前曾接受硫代苹果酸金治疗了2年,但怀孕数周时停药。硫代苹果酸金由肌注给药。给药后采集乳汁和血样并分析硫代苹果酸金含量。结果表明金的确通过血清进入乳汁。经过几天乳汁中浓度缓缓升高,而且乳汁中的浓度时间曲线
Gold preparations for the treatment of rheumatoid arthritis. There have been studies of how gold enters human milk, but the data provided and the methods used are not considered appropriate. Studies have been conducted on the use of gold thiomalate (50 mg and 70 mg, administered in divided doses for several days) in two lactating women. One of the patients had been treated with thiomalate for 2 years prior to pregnancy, but was discontinued for several weeks of pregnancy. Gold thiomalate administered by intramuscular injection. Milk and blood samples were collected after administration and the gold content of thiomalate was analyzed. The results show that gold does enter the milk through the serum. After a few days the milk concentration slowly increased, and the concentration of milk in the time curve