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目的:探讨全脑放射治疗结合三维适形放射治疗非小细胞肺癌脑转移瘤的临床效果。方法:基于2014年3月-2015年9月期间收治的60例非小细胞肺癌转移瘤患者的临床资料,按照临床治疗方式的不同,随机的将这60例患者分为对照组(采用单纯全脑放射治疗)和观察组(采用全脑放射治疗+三维适形放射治疗),两组各30例,观察比较两组患者的临床治疗效果以及并发症发生情况。结果:观察组30例患者的临床治疗客观缓解率73.3%明显的高于对照组30例患者的临床治疗总有效率46.7%,差异具有统计学意义(P<0.05);观察组30例患者的并发症发生率26.7%(共8例患者发生并发症)低于对照组30例患者的并发症发生率46.67%(共14例患者发生并发症),但差异无统计学意义(P>0.05)。结论:针对非小细胞肺癌脑转移瘤患者进行全脑放射治疗结合三维适形放射治疗,可有效控制病灶,并未明显增加不良反应,临床疗效显著,值得进一步推广。
Objective: To investigate the clinical effect of whole brain radiation therapy combined with three-dimensional conformal radiotherapy in the treatment of brain metastases of non-small cell lung cancer. Methods: Based on the clinical data of 60 patients with metastatic non-small cell lung cancer admitted from March 2014 to September 2015, the 60 patients were randomly divided into control group Brain radiotherapy) and observation group (using whole brain radiotherapy + three-dimensional conformal radiotherapy), 30 cases in each group. The clinical curative effect and complication of the two groups were observed and compared. Results: The objective response rate of clinical observation in 30 patients in the observation group was significantly higher than that in the control group (73.3%). The total effective rate was 46.7% in the 30 patients in the control group, with statistical significance (P <0.05). In the observation group of 30 patients The complication rate was 26.7% (complication in 8 patients) was lower than that in control group (46.67%) (complication occurred in 14 patients), but the difference was not statistically significant (P> 0.05) . Conclusion: Whole-brain radiation combined with three-dimensional conformal radiotherapy for patients with brain metastases of non-small cell lung cancer can effectively control the lesion without significantly increasing the adverse reactions. The clinical effect is significant and worthy of further promotion.