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目的：观察以较高尿蛋白排泄量为表现的继发肾小球疾病患儿血清蛋白及脂类变化情况。方法：对继发肾小球疾病乙肝肾炎、紫癜肾炎患儿血清总蛋白、白蛋白、胆固醇含量及２４小时尿蛋白排泄量进行测定，并与原发肾病及正常对照相比较。结果表明乙肝肾炎、紫癜肾炎组血清总蛋白、白蛋白明显低于正常组；胆固醇含量、２４小时尿蛋白排泄量明显高于正常对照（ Ｐ均＜ ０．０５），但又有别于原发肾病综合征。结论：在以较高尿蛋白排泄量为表现的继发肾小球疾病患儿机体内同样存在有蛋白及脂类代谢异常，应引起重视。
Objective: To observe the changes of serum proteins and lipids in children with glomerular disease secondary to high urinary protein excretion. Methods: Serum total protein, albumin, cholesterol and 24-hour urinary protein excretion of children with secondary glomerular disease with hepatitis B nephritis and purpura nephritis were measured and compared with primary renal disease and normal controls. The results showed that the serum total protein and albumin in hepatitis B nephritis and purpuric nephritis group were significantly lower than those in normal group, and the levels of cholesterol and 24-hour urinary protein excretion were significantly higher than those in normal control (P <0.05) Nephrotic syndrome. CONCLUSIONS: Protein and lipid metabolism abnormalities also exist in children with secondary glomerular diseases, which are characterized by high urinary protein excretion, which should be emphasized.